CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.